Antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme

摘要

The present invention relates to an antimicrobial and immunostimulatory system, applications thereof and a process for the production of the antimicrobial and immunostimulatory system. The present invention provides a storage-stable antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme, a substrate for the oxidoreductase enzyme and hydrogen peroxide in an aqueous solution wherein the substrate for the oxidoreductase enzyme is present up to 90% by weight and water is present up to 20% by weight based on the weight of the total composition; the system has a pH from approximately 4 to 8; and the system provides a two-stage hydrogen peroxide release.

主权项

1. A storage-stable antimicrobial and immunostimulatory formulation comprising glucose oxidase, D-glucose, additional sugars selected from one or more of sucrose, fructose or maltose and hydrogen peroxide in an aqueous solution;
wherein glucose oxidase is present in an amount sufficient to provide an activity of at least 10 U per 100 g of the formulation; D-glucose is present from 20 to 85% by weight based on the weight of the total formulation; additional sugars selected from one or more of sucrose, fructose or maltose are present from 5 to 70% by weight based on the weight of the total formulation; water is present from 10 to 20% by weight based on the weight of the total formulation; the formulation has a pH from approximately 4 to 8; and wherein the formulation provides a two-stage hydrogen peroxide release in which
storage-stable endogenously produced hydrogen peroxide is bioavailable within the formulation at a level of at least 10 mg per liter for immediate release; andthe sustained release of further hydrogen peroxide for at least a twenty-four hour period occurs upon administration or application of the formulation.