| 发明名称 |
SDP-containing heterobifunctional agents |
| 摘要 |
The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R1, R2, R3, Ra and L are described throughout the application. |
| 申请公布号 |
US9440925(B2) |
申请公布日期 |
2016.09.13 |
| 申请号 |
US201514810766 |
申请日期 |
2015.07.28 |
| 申请人 |
Life Technologies Corporation |
发明人 |
Gee Kyle;Chen Aimei;Kang Hee Chol |
| 分类号 |
G01N33/532;C07K1/13;C07C309/42;C07D225/08;C07D225/02;C07K16/18;C07D223/08;C07D223/26 |
主分类号 |
G01N33/532 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of making a compound of Formula IA or a salt thereof: said method comprising:
contacting a compound of Formula IB or a salt thereof: with a compound of Formula IC or a tautomer or salt thereof: whereinR1 is a halogen,R2 is a halogen,R3 comprises a water solubilizing group,L is a linker, andRa is a click-reactive group. |
| 地址 |
Carlsbad CA US |
