| 发明名称 |
Molecules of the pyrin domain protein family and uses thereof |
| 摘要 |
Diagnostic, screening and therapeutic methods utilizing NBS-1 and PYRIN-1 are disclosed. The methods take advantage of the interactions between NBS-1 or PYRIN-1 and various proteins involved in apoptotic and inflammatory signaling pathways. Also disclosed are methods for identifying modulators of ASC and NF-kappaB.
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| 申请公布号 |
US7300749(B2) |
申请公布日期 |
2007.11.27 |
| 申请号 |
US20020127516 |
申请日期 |
2002.04.22 |
| 申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
BERTIN JOHN;MANJI GULAM A. |
| 分类号 |
C12Q1/00;A61K38/00;A61K48/00;C07K14/47;G01N33/53;G01N33/68 |
主分类号 |
C12Q1/00 |
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