USE OF 2-CARBOXAMIDE CYCLOAMINO UREA DERIVATIVES IN TREATMENT OF EGFR DEPENDENT DISEASES OR DISEASES THAT HAVE ACQUIRED RESISTANCE TO AGENTS TARGETING EGFR FAMILY MEMBERS

摘要

PROBLEM TO BE SOLVED: To provide methods for treating Epidermal Growth Factor Receptor (EGFR) dependent diseases or diseases with acquired resistance to agents that target EGFR family members, and methods for producing pharmaceutical compositions for treating these diseases.SOLUTION: Provided is a therapeutic method comprising a compound represented by Formula (I) alone or in combination with an EGFR modulator selected from gefinitib, erlotinib, lapatinib, cetuximab, nimotuzumab, panitumumab, trastuzumab or TDM1.SELECTED DRAWING: None