| 发明名称 |
ANTIBODY WHICH SPECIFICALLY REACTS WITH HUMAN INTEGRIN A6B4 |
| 摘要 |
It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion. |
| 申请公布号 |
US2016194400(A1) |
申请公布日期 |
2016.07.07 |
| 申请号 |
US201414916943 |
申请日期 |
2014.09.05 |
| 申请人 |
UNIVERSITY OF MIYAZAKI ;FUJITA HEALTH UNIVERSITY ;PERSEUS PROTEOMICS INC. |
发明人 |
MORISHITA Kazuhiro;KANEDA Kazuko;KUROSAWA Yoshikazu;KUROSAWA Gene;MITOMO Katsuyuki;KOUDA Katsushi;UKAI Yoshinori |
| 分类号 |
C07K16/28;A61K31/365;A61K31/704;A61K39/395;A61K31/7068 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion. |
| 地址 |
Miyazaki JP |
