BLOOD-BRAIN BARRIER TARGETING ANTIBODIES

摘要

This invention provides antibodies that bind brain endothelial cell recep tors resulting in endocytosis/transcytosis of the receptor and bound ligands . In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the l ibrary against cultured cell monolayers. The invention further allows for id entifying endothelial cell receptors that bind the antibody thereby providin g target receptors against which to isolate further cognate ligands and thei r associated transport systems and by which to identify transcytosis transpo rters targeted by the antibodies.