| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject rapid disintegration tablets that can be readily produced by means of a general tablet machine, as it is, and has excellent disintegration properties and tablets-taking feeling with excellent operability by wet-granulating saccharides having high solubility in water and a swelling excipient and tableting the resulting granules and crystalline cellulose. SOLUTION: (A) (i) saccharides having high solubility in water, for example, sucrose, sorbitol, erythritol, xylitol or the like and (ii) a swelling excipient, for example, crystalline cellulose, crospovidone or the like are wet-granulated, preferably with a fluid type granulator or the like to prepare granules. These granules and (B) crystalline cellulose are tableted to give the objective rapid disintegration tablets. In the component A, the amount of Ai is >=40 wt.%, while the amount of Aii is <=40 wt.% and the component B is preferably 30 wt.%. When the components A and B are mixed and tableted, a lubricant such as magnesium stearate may be added thereto preferably in an amount of <=0.5 wt.% based on the whole tablet.
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