发明名称 |
ISLET AMYLOID POLYPEPTIDES WITH IMPROVED SOLUBILITY |
摘要 |
The present disclosure provides for isolated non-naturally occurring, mutant-human IAPP polypeptides. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject having an amyloid-based disease in a single injection with an insulin agent. The present disclosure also provides methods and compositions for treating amyloid-based disease in a subject in need thereof, comprising administering an effective amount of an isolated, mutant-hIAPP polypeptide, including formulations or co-formulations thereof. |
申请公布号 |
EP3137494(A2) |
申请公布日期 |
2017.03.08 |
申请号 |
EP20150786103 |
申请日期 |
2015.05.01 |
申请人 |
The Research Foundation for The State University of New York |
发明人 |
RALEIGH, Daniel;WANG, Hui;CAO, Ping;ABEDINI, Andisheh |
分类号 |
C07K14/575;A61K38/17;C07K14/47 |
主分类号 |
C07K14/575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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