| 摘要 |
PPARγ controls the expression of the TGFβ family member, GDF3, which in turn regulates the restoration of skeletal muscle integrity by promoting muscle progenitor cell differentiation. Thus, GDF3 as a secreted extrinsic effector protein acting on myoblasts and serving as an exclusively macrophage-derived regeneration factor in tissue repair. Thus, the invention relates to a GDF3 compound for use in the treatment of a patient having a condition/disease associated with impaired muscle and said patient being in need of muscle differentiation or a GDF3 compound for use in improving regeneration or differentiation of muscle of a patient in need thereof as well as pharmaceutical compositions for use in such treatments. |
