Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines

摘要

Methods for inhibiting the growth of pancreatic cancer cells or other cancer cells driven by Sonic hedgehog are disclosed. The method involves exposing the cells to 5-acyl-6,7-dihydrothieno[3,2-c]pyridines of formula (I);

主权项

1. A compound of formulaor a pharmaceutically acceptable salt thereof;wherein:
R1 and R2 are independently selected from hydrogen, halogen, (C1-C4)hydrocarbyl, (C1-C4)alkoxy, trifluoromethyl, trifluoromethoxy, cyano and nitro; R3 is R4 is selected from hydrogen, methyl, halomethyl, dihalomethyl, and trihalomethyl; and A is phenyl.