Provided is a method for enhancing the efficacy of cancer vaccines, such as tumor vaccines. The method involves administering to an individual who is in need of therapy for a tumor an anti-cancer agent and an agent that causes depletion of myeloid cells and/or inhibits recruitment of myeloid cells to the tumor. The effect of the anti-cancer agent on the tumor is greater relative to the effect of the anti-cancer agent in the absence of the anti-myeloid cell agent. Also provided is a method for identifying candidates for the therapy. This approach involves determining if an individual has a tumor characterized by undesirable myeloid cell proliferation and/or tumor infiltration and/or myeloid cell recruitment to the tumor, and if such determination is made, designating the individual as a candidate for the therapy. In one embodiment, the identification of the individual as such a candidate is followed by the therapeutic approach.
申请公布号
EP2968557(A1)
申请公布日期
2016.01.20
申请号
EP20140775563
申请日期
2014.03.13
申请人
HEALTH RESEARCH, INC.
发明人
SEGAL, BRAHM, H.;ABRAMS, SCOTT;ODUNSI, KUNLE;GRIMM, MELISSA;KHAN, NAZMUL, H.;KOLOMEYEVSKAYA, NONNA;SINGEL, KELLY