发明名称 |
NOVEL EPOPROSTENOL FORMULATION AND METHOD OF MAKING THEREOF |
摘要 |
This invention relates to a stable epoprostenol composition that can be combined with commercially available IV fluids and can be administered in its reconstituted and/or diluted form under ambient conditions of about 15-30° C. for greater than 24 hours. The composition preferably contains (a) epoprostenol or a salt thereof; (b) a alkalinization agent; and (c) a base, such that when reconstituted or in solution, the solution has a pH>11. Methods for making the lyophilized composition are also disclosed. |
申请公布号 |
EP1993557(B1) |
申请公布日期 |
2015.11.11 |
申请号 |
EP20070763188 |
申请日期 |
2007.02.02 |
申请人 |
ACTELION PHARMACEUTICALS LTD. |
发明人 |
PALEPU, NAGESH R. |
分类号 |
A61K31/557;A61K9/00;A61K9/08;A61K9/19;A61K31/5585;A61K47/02;A61K47/18;A61K47/26 |
主分类号 |
A61K31/557 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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