| 发明名称 | Compositions and methods for binding lysophosphatidic acid | ||
| 摘要 | Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described. Variable domain and complementarity determining region amino acid sequences of several monoclonal antibodies against LPA are disclosed, as is a consensus anti-LPA monoclonal antibody variable domain sequence. | ||
| 申请公布号 | US9163091(B2) | 申请公布日期 | 2015.10.20 |
| 申请号 | US200912406874 | 申请日期 | 2009.03.18 |
| 申请人 | Lpath, Inc. | 发明人 | Sabbadini Roger A.;Garland William A.;Hansen Genevieve;Swaney James Stephen;Matteo Rosalia;Mills Gordon;Wojciak Jonathan Michael |
| 分类号 | G01N33/92;C07K16/30;C07K16/18;A61K39/00;C12Q1/68 | 主分类号 | G01N33/92 |
| 代理机构 | Acuity Law Group, P.C. | 代理人 | Acuity Law Group, P.C. ;Chambers Daniel M. |
| 主权项 | 1. A diagnostic reagent comprising a derivatized lysophosphatidic acid (LPA) conjugated to a solid support or carrier, wherein the derivatized LPA is selected from the group consisting of 18:2, 18:1, 18:0, 16:0 and 20:4 LPA, and wherein the hydrocarbon chain of the derivatized LPA includes a reactive group at the most distal carbon position of the hydrocarbon chain. | ||
| 地址 | San Diego CA US | ||