| 发明名称 |
Acylated glucagon analogues |
| 摘要 |
The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes and associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon. |
| 申请公布号 |
US9156901(B2) |
申请公布日期 |
2015.10.13 |
| 申请号 |
US201013383783 |
申请日期 |
2010.06.24 |
| 申请人 |
|
发明人 |
Riber Ditte;Meier Eddi;Daugaard Jens Rosengren;Skovgaard Marie;Tolborg Jakob Lind;Kampen Gita;Bæk Camilla Ærteberg |
| 分类号 |
A61K38/26;A61P3/10;A61P7/12;C07K14/605 |
主分类号 |
A61K38/26 |
| 代理机构 |
Clark & Elbing LLP |
代理人 |
Clark & Elbing LLP ;Bieker-Brady Kristina |
| 主权项 |
1. A compound having the formula:
R1—Z—R2 wherein R1 is H, C1-4 alkyl, formyl, benzoyl or trifluoroacetyl; R2 is OH or NH2; and Z is a peptide having the formula H-Aib-QGTFTSDYSKYLDS-K(Hexadecanoyl- γ-Glu)-AAHDFVEWLLSA (SEQ ID NO: 89), or a salt thereof. |
| 地址 |
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