发明名称 |
OLIGOMERIC COMPOUNDS COMPRISING TRICYCLIC NUCELOSIDES AND METHODS FOR THEIR USE |
摘要 |
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. |
申请公布号 |
US2015259681(A1) |
申请公布日期 |
2015.09.17 |
申请号 |
US201514628044 |
申请日期 |
2015.02.20 |
申请人 |
Isis Pharmaceuticals, Inc. |
发明人 |
Swayze Eric E.;Siwkowski Andrew M.;Seth Punit P.;Prakash Thazha P. |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Carlsbad CA US |