ARTIFICIAL MATCH-TYPE MIRNA FOR CONTROLLING GENE EXPRESSION AND USE THEREFOR

摘要

The present invention provides an artificial match-type miRNA that is a single-stranded nucleic acid comprising an X region and a Y region and that is characterized in that: the 3'-end of the X region and the 5'-end of the Y region are connected via a non-nucleotide structure that comprises at least one of a pyrrolidine skeleton and a piperidine skeleton; the X region comprises an hsa-miR-34 mature miRNA guide strand sequence; and the Y region comprises a sequence that is perfectly complementary to the X region. This artificial match-type miRNA makes it possible to inhibit the expression of a target gene.