发明名称 |
Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient |
摘要 |
Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R1, R2, R2′, R3 and R3′ independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N—R11, a sulfur atom, or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; B represents a C6-14 aryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt. |
申请公布号 |
US9045423(B2) |
申请公布日期 |
2015.06.02 |
申请号 |
US201414274805 |
申请日期 |
2014.05.12 |
申请人 |
KOWA COMPANY, LTD. |
发明人 |
Ashikawa Masanori;Tagashira Junya;Koketsu Akiyasu;Morimoto Toshiharu;Kitamura Takahiro;Takemura Syunji;Watanabe Gen;Nishiyama Tatsuaki;Goda Satoshi;Yamabi Masaki;Doi Takeshi;Ishiwata Hiroyuki |
分类号 |
A01N57/26;A61K31/675;C07D215/42;A61K31/47;A61K31/4706;A61K31/4709;A61K31/496;A61K31/5377;A61K31/69;C07D215/233;C07D215/44;C07D215/46;C07D215/48;C07D401/04;C07D401/12;C07D413/04;C07D413/12;C07D417/12;C07D405/12 |
主分类号 |
A01N57/26 |
代理机构 |
Westerman, Hattori, Daniels & Adrian, LLP |
代理人 |
Westerman, Hattori, Daniels & Adrian, LLP |
主权项 |
1. A tetrahydroquinoline compound, a salt thereof, or a solvate of the compound, wherein the tetrahydroquinoline compound is 1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamide (compound 43). |
地址 |
Nagoya-shi JP |