| 摘要 |
PROBLEM TO BE SOLVED: To provide compositions for treating c-Kit associated inflammatory, fibrotic, autoimmune and cancerous diseases, and to provide compositions containing humanized c-Kit antibodies.SOLUTION: This invention relates to compositions and methods for treating c-Kit associated disorders such as fibrosis, and more particularly, to compositions containing humanized c-Kit antibodies. The invention provides agents that are antagonists and neutral antagonists of SCF at the cell-associated and membrane c-Kit receptor, such as monoclonal antibodies. Humanized (non-murine) monoclonal antibodies that bind c-Kit are provided. The invention also provides nucleic acid sequence encoding any of the antibodies or specific binding agents. |
