Slow release liquid drug delivery device

摘要

A drug delivery device includes a first portion, formed primarily from elastomeric material, and a closure portion, cooperating with an opening of the first portion so as to complete an inflatable drug reservoir. The closure portion extends into the first portion inwards from the opening, defining at least one region of overlap between the first portion and the closure portion. The first portion and the closure portion define an outlet flow path for releasing a drug from the drug reservoir, with at least part of the outlet flow path passing between the first portion and the closure portion in the region of overlap. The region of overlap is disposed so as to be acted upon by a pressure within the drug reservoir thereby changing a flow impedance of the outlet flow path to provide an at least partially pressure compensated flow regulating mechanism.

主权项

1. A drug delivery device providing a drug reservoir integrated with an at least partially pressure-compensated flow regulating mechanism, the drug delivery device comprising:
(a) a first portion formed primarily from elastomeric material, said first portion at least partially defining an inflatable drug reservoir, said first portion having an opening and a flexible sleeve extending inwards from said opening; and (b) a closure portion cooperating with said opening of said first portion so as to complete said inflatable drug reservoir,wherein said closure portion is implemented as an insert inserted within said flexible sleeve so as to provide a region of overlap between said first portion and said closure portion, said insert being sized to provide pre-tensioning of said inflatable drug reservoir around said insert,and wherein said first portion and said closure portion define an outlet flow path for releasing a drug from said drug reservoir, at least part of said outlet flow path passing between said first portion and said closure portion in said region of overlap, said region of overlap being disposed so as to be acted upon by a pressure within said drug reservoir so as to change a flow impedance of said outlet flow path when the pressure within the reservoir varies, thereby providing an at least partially pressure compensated flow regulating mechanism.