发明名称 |
Compositions and methods for modification of biomolecules |
摘要 |
Provided are modified cycloalkyne compounds; and methods of use of such compounds in modifying biomolecules. Embodiments include a cycloaddition reaction that can be carried out under physiological conditions. The cycloaddition reaction involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo and in vitro.
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申请公布号 |
US8519122(B2) |
申请公布日期 |
2013.08.27 |
申请号 |
US201113024908 |
申请日期 |
2011.02.10 |
申请人 |
JEWETT JOHN C.;BERTOZZI CAROLYN RUTH;SLETTEN ELLEN MAY;GORDON CHELSEA GLORIA;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
JEWETT JOHN C.;BERTOZZI CAROLYN RUTH;SLETTEN ELLEN MAY;GORDON CHELSEA GLORIA |
分类号 |
C07D225/04 |
主分类号 |
C07D225/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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