发明名称 |
NUCLEIC ACID DELIVERY COMPOSITION AND CARRIER COMPOSITION, PHARMACEUTICAL COMPOSITION USING THE SAME, AND METHOD FOR DELIVERING NUCLEIC ACID |
摘要 |
An excellent nucleic acid delivery composition is provided which has reduced cytotoxicity and improved nucleic acid introduction efficiency and gene expression efficiency. The composition comprises: a block copolymer having an uncharged hydrophilic polymer segment and a cationic polymer segment; a cationic polymer; and a nucleic acid, wherein the mol percentage (B/H ratio) of the cationic groups of the block copolymer to the total cationic groups of the block copolymer and the cationic polymer is between 25% and 90%.
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申请公布号 |
US2013109743(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
US201113808237 |
申请日期 |
2011.07.11 |
申请人 |
KATAOKA KAZUNORI;ISHII TAKEHIKO;OSADA KENSUKE;CHEN QIXIAN;ITAKA KEIJI;UCHIDA SATOSHI;THE UNIVERSITY OF TOKYO |
发明人 |
KATAOKA KAZUNORI;ISHII TAKEHIKO;OSADA KENSUKE;CHEN QIXIAN;ITAKA KEIJI;UCHIDA SATOSHI |
分类号 |
A61K47/34 |
主分类号 |
A61K47/34 |
代理机构 |
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