发明名称 |
Designer ubiquitin ligases having a non-cleavable SNAP25 domain and E3-ligase domain |
摘要 |
The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes a toxin binding domain that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes; and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention.
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申请公布号 |
US8343743(B2) |
申请公布日期 |
2013.01.01 |
申请号 |
US20090482420 |
申请日期 |
2009.06.10 |
申请人 |
SYNAPTIC RESEARCH, LLC;OYLER GEORGE A.;TSAI YIEN CHE |
发明人 |
OYLER GEORGE A.;TSAI YIEN CHE |
分类号 |
C12N9/00;A61K38/43;C07H21/04;C12N1/20;C12N15/00 |
主分类号 |
C12N9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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