METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

摘要

Methods for identifying a cancer in a subject by measuring the expression level or biological activity of the following genes or proteins encoded by said genes: mTOR or PI3K and of one or more of IGFIR, B-bcl-2, src, rsk, FAK, VEGF, and PERK in the sample; where a decrease in the expression level or biological activity of mTOR or PI3K, and an increase in the expression level or biological activity of one or more of IGFIR, bcl-2, src, rsk, FAK, VEGF, and PERK identifies a cancer in the subject, as well as pharmaceutical compositions, kits, and methods for treating a subject diagnosed with, or at risk of developing cancer, by administering inhibitors of said genes or proteins encoded by said genes.