发明名称 |
PROCESS FOR PREPARING GRANULAR COMPOSITIONS |
摘要 |
A process for the preparation of a granular composition comprising solidified melt granules comprising a non-steroidal anti-inflammatory drug (NSAID) as a continuous phase, which process comprising the steps of: (a) melt-extruding the NSAID, optionally with excipients; (b) forming a homogeneous extrudate; (c) cooling the extrudate; and (d) comminuting the cooled extrudate to form granules; characterised in that in the step (a) the NSAID is fully melted and that in step (b) the extrudate is formed into two or more ribbons having a depth of 10 mm or less and which solidify in 5 minutes or less. |
申请公布号 |
CA2449356(C) |
申请公布日期 |
2011.11.29 |
申请号 |
CA20022449356 |
申请日期 |
2002.05.30 |
申请人 |
THE BOOTS COMPANY PLC |
发明人 |
SHERRY, ROBERT ARTHUR;DRING, RICHARD JAMES;EDINBOROUGH, NICHOLAS DAVID |
分类号 |
A61K9/16;A61J3/02;A61K9/20;A61K31/192;A61K45/00;A61P15/00;A61P19/02;A61P19/10;A61P25/04;A61P29/00;B01J2/00;B01J2/20;B02C23/08;B30B11/22;B30B11/24 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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