摘要 |
The present invention provides a process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives of formula I, and its pharmaceutically acceptable salts thereof from intermediate of formula II, wherein R1 can be selected from -OR2, halo, -CH2OR2, -SR2, SOR2, SO2R2, -SO3H, -NO2, -NR2R2', - CONR2R2 ', carboxylic esters, sulfonate esters or phosphate esters and the like; R ' can be selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, heteroaryl, and the like; or OR ' can be selected from -NR2R2 '; or R2 and R2 ' can be same or different and can be selected from hydrogen, alkyl, aryl, aralkyl, heteroaryl,-OR3, - COR3, -PO3(R3R4) wherein R3 and R4 can be same or different and can be selected from alkyl, aryl, aralkyl, heteroaryl and the like. |
申请人 |
IND-SWIFT LABORATORIES LIMITED;BHIRUD, SHEKHAR BHASKAR;JOHAR, PERMINDER SINGH;SHARMA, EKTA;JAMSHAD, DANISH;PRAJAPATY, RAMKARAN |
发明人 |
BHIRUD, SHEKHAR BHASKAR;JOHAR, PERMINDER SINGH;SHARMA, EKTA;JAMSHAD, DANISH;PRAJAPATY, RAMKARAN |