发明名称 |
Bispecific Oligonucleotide for the Treatment of CNS Malignancies |
摘要 |
CNS malignancy is treated in a subject suffering from a CNS malignancy by administering to the subject an antisense oligonucleotide having a sequence of bases that is complementary to portions of both the gene encoding IGFBP-2 and the gene encoding IGFBP-5, and which is of sufficient length to act as an inhibitor of the effective amount of IGFBP-2 and IGFBP-5, in an amount effective to reduce effective levels of IGFBP-2 and IGFBP-5 in cells of the CNS malignancy.
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申请公布号 |
US2011152354(A1) |
申请公布日期 |
2011.06.23 |
申请号 |
US201113004421 |
申请日期 |
2011.01.11 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
GLEAVE MARTIN E.;POLLAK MICHAEL N.;LEVITT RANDY J. |
分类号 |
A61K31/7088;A61K31/7115;A61K48/00;A61P25/00;A61P35/00;A61P35/04;C12N5/09;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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