According to one aspect of the invention, implantable or insertable medical devices are provided which can delay release of one or more therapeutic agents for a predetermined time after implantation in a subject. In various embodiments, a therapeutic agent delivery profile of this type is provided by employing a temporary barrier layer which initially permits little to no release of the therapeutic agent, but which layer permits much greater release levels after a predetermined period of time. Other aspects of the invention relate to methods of forming such devices and to methods of using such devices.
申请公布号
WO2011022623(A2)
申请公布日期
2011.02.24
申请号
WO2010US46125
申请日期
2010.08.20
申请人
BOSTON SCIENTIFIC SCIMED, INC.;HINGSTON, JOHN;ROBICHAUD, MICHAEL;WEBER, JAN;MCNAMARA, ADRIAN;FLANAGAN, AIDEN;HORGAN, FERGAL