| 摘要 |
Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin Bi and [lie7] polymyxin Bi. The novel compounds have antibacterial properties against a diverse range of gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin B. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds. |
