TUMOR TREATMENT TECHNIQUE USING LIPOSOME ENCAPSULATING AMMINE-PLATINUM COMPLEX AT HIGH CONCENTRATION

摘要

Provided is a therapeutic agent containing an ammine-platinum complex (particularly cisplatin) which has less side effects and specifically acts on tumor or cancer; and a method using the same.  Also provided is a composition for treating cancer or tumor.  This composition contains cis-diamminedichloroplatinum (II), and liposome contains a target-directed substance on the surface thereof.  In one embodiment, the target-directed substance is selected from the group consisting of antibodies and sugar chains.  In a preferred embodiment, the target-directed substance is sialyl Lewis-X or anti-E-selectin antibody.  In one embodiment, the cancer or tumor is selected from the group consisting of colon cancer, lung cancer, squamous cell carcinoma, breast cancer and ovarian cancer.