摘要 |
The present invention relates to a method for the production of an anti-cancer effect in a warm-blooded animal such as a human, which comprises administering to said animal an effective amount of a compound of Formula (I) wherein X represents at any available ring position -CONH-, -SO<SUB>2</SUB>NH-, -O-, -CH<SUB>2</SUB>-, NHCO- or -NHSO<SUB>2</SUB>-; R represents a lower C1-6 alkyl optionally substituted with one or more groups including hydroxyl, amino and N-oxides therefrom or dialkylamino and N-oxides therefrom; Y represents at any available ring position -N-aziridinyl, -N(CH<SUB>2</SUB>CH<SUB>2</SUB>W)<SUB>2 </SUB>or -N(CH<SUB>2</SUB>CHMeW)<SUB>2</SUB>, where each W is independently selected from halogen or -OS0<SUB>2</SUB>Me; Z represents at any available ring position -NO<SUB>2</SUB>, -halogen, -CN, -CF<SUB>3</SUB>, or -SO<SUB>2</SUB>Me; or a pharmaceutically acceptable salt or derivative thereof, before, after or simultaneously with an effective amount of docetaxel. |