发明名称 |
Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof |
摘要 |
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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申请公布号 |
US2009208590(A1) |
申请公布日期 |
2009.08.20 |
申请号 |
US20090369549 |
申请日期 |
2009.02.11 |
申请人 |
ADAMS JULIAN;GAO YUN;EVANGELINOS ASIMINA T GEORGES;GRENIER LOUIS;PAK ROGER H;PORTER JAMES R;WRIGHT JAMES L |
发明人 |
ADAMS JULIAN;GAO YUN;EVANGELINOS ASIMINA T. GEORGES;GRENIER LOUIS;PAK ROGER H.;PORTER JAMES R.;WRIGHT JAMES L. |
分类号 |
A61K33/24;A61K31/33;A61K31/337;A61K31/496;A61K31/505;A61K31/69;A61K31/7068;A61P35/00;C07D211/60;C07D225/06;C07D498/08;C07F5/02;C07F9/6561 |
主分类号 |
A61K33/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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