发明名称 |
Screening method for agents suitable for therapy of Alzheimer's disease |
摘要 |
Described is a method of screening for therapeutic agents for the prophylaxis and therapy of Alzheimer's disease (AD), wherein agents that (i) do not interfere with the biological activity of gamma-secretase, (ii) do not exhibit cytotoxicity, (iii) lead to reduced amounts of Abeta42 and (iv) are capable of binding to an APP-GxxxG motif thereby weakening or inhibiting dimerization of the APP transmembrane sequence are suitable for prophylaxis or treatment of AD.
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申请公布号 |
EP2065472(A1) |
申请公布日期 |
2009.06.03 |
申请号 |
EP20070022923 |
申请日期 |
2007.11.27 |
申请人 |
FU BERLIN |
发明人 |
MULTHAUP, GERD, PROF.;MUENTER, LISA-MARIE |
分类号 |
C12Q1/37;G01N33/68 |
主分类号 |
C12Q1/37 |
代理机构 |
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地址 |
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