PROCESS FOR PREPARING USEFUL IN SYNTHESIS OF MONTELUKAST

摘要

Provided is a method for mass production of montelukast having leukotriene antagonism, which can treat asthma disease, diseases related to immunity, and respiratory disease such as allergic rhinitis. A method for mass production of montelukast represented by the formula 1 comprises the following steps of: reacting a (S)-diol compound represented by the formula 2 through a Mitsnobu reaction to prepare a (S)-phosphine oxo-compound wherein sec-alcohol groups are activated, represented by the formula 3 in the presence of a phosphine compound; and coupling the (S)-phosphine oxo-compound with 1-(mercaptomethyl) cyclopropane acetic acid represented by the formula 4a.