| 摘要 |
PROBLEM TO BE SOLVED: To provide a percutaneous absorption pharmaceutical preparation comprising insulin which excels in percutaneous absorption, has low skin irritation, and high safety and usability, and a percutaneous absorption system using the same. SOLUTION: The percutaneous absorption pharmaceutical preparation comprises an insulin aspart aqueous solution having a pH of 7-8 and the percutaneous absorption system comprises pretreating the skin with oxygen and thereafter applying the percutaneous absorption preparation to the skin, and the percutaneous absorption system comprises pretreating the skin with oxygen, then treating the skin with an oxygen passivating substance, and thereafter applying the percutaneous absorption pharmaceutical preparation to the skin. COPYRIGHT: (C)2009,JPO&INPIT
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