发明名称 |
SHRNA AND SIRNA AND MIRNA EXPRESSION IN A LIVING ORGANISM UNDER CONTROL OF A CODON-OPTIMIZED REPRESSOR GENE |
摘要 |
The present invention relates to a biological entity, notably a rat, carrying a regulator construct comprising a specific repressor gene and a responder construct comprising at least one segment corresponding to a short hairpin RNA (shRNA) or corresponding to complementary short interfering RNA (siRNA) strands or corresponding to miRNA, said at least one segment being under control of a promoter which contains an operator sequence corresponding to the repressor. The invention further relates to a method for preparing said biological entity and its use.
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申请公布号 |
US2009025097(A1) |
申请公布日期 |
2009.01.22 |
申请号 |
US20080118025 |
申请日期 |
2008.05.09 |
申请人 |
ARTEMIS PHARMACEUTICALS GMBH |
发明人 |
SEIBLER JOST;SCHWENK FRIEDER;KUTER-LUKS BIRGIT;BADER MICHAEL;KOTNIK KATARINA |
分类号 |
C12N15/09;A01K67/027;C12N5/10;C12N15/11 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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