发明名称 |
LYOPHILIZED FORMULATIONS OF ANTI-EGFR ANTIBODIES |
摘要 |
In one embodiment, the present invention provides a stable lyophilized formulation comprising an anti-EGFR antibody, preferably cetuximab; lactobionic acid; and a buffer, preferably histidine. In one preferred embodiment, the present invention provides a stable lyophilized formulation comprising about 50 mg/mL to about 140 mg/mL of ERBITUX?, about 0.125% lactobionic acid, about 25 mM histidine buffer at a pH of about 6.0, about 0.005% Tween 80, and about 1.875% glycine. |
申请公布号 |
WO2007147001(A3) |
申请公布日期 |
2008.07.10 |
申请号 |
WO2007US71119 |
申请日期 |
2007.06.13 |
申请人 |
IMCLONE SYSTEMS INCORPORATED;AGARKHED, MEERA;SRIVASTAVA, ARVIND;GOLDSTEIN, JOEL |
发明人 |
AGARKHED, MEERA;SRIVASTAVA, ARVIND;GOLDSTEIN, JOEL |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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