发明名称 |
Reagents, Methods and Systems for Selecting a Cytotoxic Antibody or Variant Thereof |
摘要 |
The present invention provides reagents, methods and systems for predicting the cytotoxic activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor, and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio), wherein the magnitude of said ratio is an indication of the cytotoxic activity of the antibody or variant thereof. The present invention also provides purified modified antibodies having altered A/I ratios as compared to the unmodified antibodies. |
申请公布号 |
US2008286819(A1) |
申请公布日期 |
2008.11.20 |
申请号 |
US20060092235 |
申请日期 |
2006.10.27 |
申请人 |
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发明人 |
RAVETCH JEFFREY V.;NIMMERJAHN FALK |
分类号 |
G01N33/53;C07K16/00;G01N33/566 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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