NOVEL POLYMORPH FORM E OF OLANZAPINE (2-METHYL-4- (4-METHYL-1-PIPERAZINYL) -10H-THIENO [2, 3-B] [1, 5] BENZODIAZEPINE) AND PREPARATION OF THE ANHYDROUS NON-SOLVATED CRYSTALLINE POLYMORPHIC FORM I OF OLANZAPINE FROM THE POLYMORPHIC OLANZAPINE FO

摘要

The invention provides an Olanzapine pseudopolymoph Form E. The invention provides methods of preparing polymorphic Olanzapine Form E employing rapid crystallization and seeding. The invention provides methods of preparing anhydrous Olanzapine Form I from the Olanzapine Form E by step-wise drying.