发明名称 |
BIOMARKER SENSORS AND METHOD FOR MULTI-COLOR IMAGING AND PROCESSING OF SINGLE-MOLECULE LIFE SIGNATURES |
摘要 |
<p>A device comprising an array of active regions for use in reacting one or more species in at least two of the active regions in a sequential process, e.g., sequential reactions. The device has a transparent substrate member, which has a surface region. The device has a silane material overlying the surface region. The device has a first active region formed overlying a first portion of the silane material. In a specific embodiment, the first active region has a first dimension of less than 1 micron in size and has one or more first molecules capable of binding to the first portion of the silane material. In a specific embodiment, the device has a second active region formed overlying a second portion of the silane material. The second active region has a second dimension of less than 1 micron in size and has one or more second molecules capable of binding to the second portion of the active region. In a specific embodiment, the device has a spatial distance separating the first active region and the second active region. In a preferred embodiment, the spatial distance is characterized by a dimension of 1 micron and less. The device has a fluid material in contact with the first active region, the second active region, and the spatial distance according to a specific embodiment. The device also has a reactant species within the fluid material. The reactant species is capable of spatially moving from the first active region to the second active region over the spatial distance of 1 micron and less within a time of less than 10 microseconds.</p> |
申请公布号 |
WO2007046819(A2) |
申请公布日期 |
2007.04.26 |
申请号 |
WO2005US41954 |
申请日期 |
2005.11.15 |
申请人 |
CALIFORNIA INSTITUE OF TECHNOLOGY;WADE, LAWARENCE, A.;COLLIER, CHARLES, PATRICK |
发明人 |
WADE, LAWARENCE, A.;COLLIER, CHARLES, PATRICK |
分类号 |
C12Q1/68;C12M1/34;C12M3/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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