发明名称 |
Indoline and tetrahydro-quinolines as prodrugs for tumour treatment |
摘要 |
Compounds of the general formula I or IA or a salt in which X is H, Y is a leaving group, R<SUP>1 </SUP>preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which X is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumours. The prodrug is expected to be activated preferentially in tumour cells, where it will act as a DNA alkylating agent preventing cell division
|
申请公布号 |
US7179921(B2) |
申请公布日期 |
2007.02.20 |
申请号 |
US20040468743 |
申请日期 |
2004.03.29 |
申请人 |
SCHOOL OF PHARMACY, UNIVERSITY OF LONDON |
发明人 |
SEARCEY MARK;PATTERSON LAURENCE HYLTON |
分类号 |
C07D215/02;C07D215/18;A61K31/40;A61K31/404;A61K31/47;A61K31/4709;A61P35/00;A61P43/00;C07D209/04;C07D209/26;C07D209/42;C07D215/08;C07D401/06;C07D487/04 |
主分类号 |
C07D215/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|