| 摘要 |
[PROBLEMS] To provide a polymeric pharmaceutical agent which can contain the active ingredient in a larger amount, which can be highly accumulated in tumor tissues, and which has a molecular size that is large enough not to undergo the renal excretion. [MEANS FOR SOLVING PROBLEMS] The polymeric pharmaceutical agent capable of containing the active ingredient in a large amount can be produced by forming a styrene-maleic acid copolymer (SMA) micelle complex comprising a metalloporphyrin derivative (e.g., zinc protoporphyrin) and an SMA conjugated to each other via non-covalent bonding. This SMA micelle complex can be produced by reacting a metalloporphyrin derivative with an SMA in the absence of a condensing agent under alkaline conditions, solubilizing the resulting product, adjusting the reaction to pH 6 to 8, and collecting a polymeric micelle complex component having the active ingredient contained therein by a procedure for separating a polymeric component. |
