| 摘要 |
FIELD: organic chemistry, medicine, oncology. ^ SUBSTANCE: invention proposes using derivatives of N-substituted indole-3-glyoxylamide of the formula (1) as an antitumor medicinal agent and/or agent inhibiting angiogenesis (variants), and an antitumor medicinal agent (variants). The claimed derivatives are known as immunomodulating agents. Invention revealed both an antitumor activity of indicated compounds, among them, under conditions for arising the medicinal resistance (cytotoxic effect) and their inhibitory effect on angiogenesis. This allows using these compounds in treatment of tumors including leukemia and metastasizing carcinoma, or in treatment of other diseases wherein the suppression of angiogenesis is required (for example, in wound healing). ^ EFFECT: valuable medicinal properties of agent. ^ 13 cl, 9 dwg |
