发明名称 |
AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES |
摘要 |
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent.
|
申请公布号 |
WO2006014381(A9) |
申请公布日期 |
2006.04.13 |
申请号 |
WO2005US23617 |
申请日期 |
2005.07.01 |
申请人 |
UNIVERSITY OF PITTSBURGH;KLUNK, WILLIAM E.;MATHIS, CHESTER, A., JR |
发明人 |
KLUNK, WILLIAM E.;MATHIS, CHESTER, A., JR |
分类号 |
A61K49/00;A61K49/04;A61K49/08;A61K51/04 |
主分类号 |
A61K49/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|