摘要 |
Described herein is a gene therapeutic approach to the prevention and treatment of vascular disease and coronary heart disease; in particular, atherosclerosis. The inventive methods may be used in the prevention and treatment of atherosclerosis, as well as any disease or physiological condition in which atherosclerosis plays a role. The inventive methods involve the gene delivery of ApoA-I or ApoA-IMilano. This may be accomplished by the use of rAAV technology. rAAV virions may be delivered to a mammalian subject by various methodologies, including transplantation of transduced bone marrow cells, direct intramuscular injection, intravenous or portal vein injection or stent delivery. |
申请人 |
CEDARS-SINAI MEDICAL CENTER;CITY OF HOPE;SHAH, PREDIMAN, K.;CHATTERJEE, SASWATI;WONG, KAMEHAMEHA, KAY-MIN, JR |
发明人 |
SHAH, PREDIMAN, K.;CHATTERJEE, SASWATI;WONG, KAMEHAMEHA, KAY-MIN, JR |