Simvastatin formulations and methods of making same

摘要

The invention encompasses a compositions of at least one statin, at least one pharmaceutically acceptable solvent, and at least one surface active agent. In the composition, about 9% to about 50% by weight of the statin is hydrolyzed from a closed lactone form to an open hydroxy acid form when the composition is placed in an aqueous acidic solution. The invention also encompasses method of making the composition and methods of treating high cholesterol, multiple sclerosis, and/or Alzheimer's disease using the compositions described herein.