发明名称 |
SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES AS LIGANDS AT ALPHA 7 NICOTINIC ACETY LCHOLINE RECEPTORS |
摘要 |
Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4- (methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by .alpha.7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I ) and methods for using such compounds and compositions.
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申请公布号 |
CA2538789(A1) |
申请公布日期 |
2005.03.31 |
申请号 |
CA20042538789 |
申请日期 |
2004.09.17 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
JI, JIANGUO;SCHRIMPF, MICHAEL R.;NERSESIAN, DIANA L.;MORTELL, KATHLEEN H.;RYTHER, KEITH B.;PACE, JENNIFER M.;TIETJE, KARIN R.;BUNNELLE, WILLIAM H.;DART, MICHAEL J.;GALLAGHER, MEGAN E.;BASHA, ANWER;LI, TAO |
分类号 |
C07D471/04;A61K31/435;A61P25/00;C07D471/08;C07D487/04;C07D487/08 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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