发明名称 |
Process and intermediates to prepare latanoprost. |
摘要 |
The present invention is a novel intermediate, compound of the formula (VI)and salts thereof. In addition, the invention includes a process for the preparation of a 15(S)-prostaglandin intermediates compounds (IV) and (XVIII) which comprises (1) contacting a the corresponding enone with (-)-chlorodiisopinocampheylborane while maintaining the reaction mixture temperature in the range of from about -50° to about 0° and (2) contacting the reaction mixture of step (1) with a boron complexing agent. |
申请公布号 |
ZA200400163(B) |
申请公布日期 |
2005.01.10 |
申请号 |
ZA20040000163 |
申请日期 |
2004.01.09 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
HENEGAR, KEVIN, E. |
分类号 |
C07D307/83;A61K31/5575;A61P27/02;C07C59/11;C07C59/54;C07C59/72;C07C405/00;C07D307/935 |
主分类号 |
C07D307/83 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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