| 摘要 |
The present invention relates generally to a method of eliciting or otherwise inducing an immune response to a virus and agents for use therein. More particularly, the present invention relates to a method of eliciting or otherwise inducing an immune response to HIV and to agents for use therein. The method of the present invention is predicated on the application of a novel prime-boost vaccination regime utilising, respectively, a CpG optimised plasmid vector and a viral vector, both of which encode two or more substantially non-pathogenic HIV antigens. The present invention is useful, inter alia, as a prophylactic and/or therapeutic treatment regime for viral pathogen infections of mammals such as, for example, HIV infection. A related aspect of the present invention is directed to the optimised vectors for use in this method. |
| 申请人 |
THE UNIVERSITY OF NEW SOUTH WALES;KENT, STEPHEN, J.;PURCELL, DAMIAN, F.;BOYLE, DAVID, B.;RAMSAY, ALISTAIR;THOMSON, SCOTT;RAMSHAW, IAN, A |
发明人 |
KENT, STEPHEN, J.;PURCELL, DAMIAN, F.;BOYLE, DAVID, B.;RAMSAY, ALISTAIR;THOMSON, SCOTT;RAMSHAW, IAN, A |
