发明名称 |
Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors |
摘要 |
A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclic group; as well as compounds of formula (I) which are derivatised at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme.
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申请公布号 |
US2004106627(A1) |
申请公布日期 |
2004.06.03 |
申请号 |
US20030333431 |
申请日期 |
2003.07.09 |
申请人 |
GARDELLI CRISTINA;GIULIANO CLAUDIO;HARPER STEVEN;KOCH UWE;NARJES FRANK;ONTORIA ONTORIA JESUS MARIA;POMA MARCO;PONZI SIMONA;STANSFIELD IAN;SUMMA VINCENZO |
发明人 |
GARDELLI CRISTINA;GIULIANO CLAUDIO;HARPER STEVEN;KOCH UWE;NARJES FRANK;ONTORIA ONTORIA JESUS MARIA;POMA MARCO;PONZI SIMONA;STANSFIELD IAN;SUMMA VINCENZO |
分类号 |
A61K31/513;A61P1/16;A61P31/12;A61P31/14;A61P43/00;C07D239/54;C07D239/557;C07D401/12;C07D405/12;C07D409/04;C07D409/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D417/14;(IPC1-7):A61K31/519;A61K31/506;C07D487/02;C07D417/02;C07D413/02;C0743/02 |
主分类号 |
A61K31/513 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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