| 摘要 |
The present invention relates to an antibody characterised in that it comprises at least one antibody-antigen binding site, exhibits specific binding to human complement component C5, said specific binding being targeted to the alpha chain of human complement component C5, inhibits complement activation in a human body fluid and does not specifically bind to the human complement activation product free C5a, wherein the antibody binds specifically with (i) a fragment comprising amino acid residues 660-1019 of SEQ ID NO:2; (ii) a peptide comprising amino acid residues 725-1049 of SEQ ID NO:2; (iii) a peptide comprising amino acid residues 850-1049 of SEQ ID NO:2; or (iv) a peptide comprising the amino acid sequence of SEQ ID NO:1.
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